Bringing short. positive episodes to the Low Carb community highlighting success stories from individuals and practitioners as well as tips and tricks and some great recipes. We know your time is precious so our aim is to get you out of the door in less than 20 minutes.
We hope to never have to insert commercials in our podcasts, but the work we do to put on these educational events, build the community and develop and maintain the Clinical Guidelines is not sustainable without your support. Please consider becoming a patron. We have now introduced tiers for Loyal Patrons to get early access to podcast episodes as well as really cool bonus material. Even the smallest contribution helps! Please, also, subscribe to our show on Stitcher or iTunes to help us reach more people.
Apr 28, 2020
Dr. Lewis Cantley has made significant advances in cancer research stemming from his discovery of the signalling pathway phosphoinositide 3-kinase (Pi3K) in 1984. It is an enzyme that mediates pretty much everything that insulin does, in the liver, in the fat cells, and it mediates the lowering of serum glucose levels because it drives glucose into the muscle, AND into tumours. Since tumours thrive on glucose, they thought to develop a Pi3 Kinase inhibitor in order to try to treat tumours but the inhibitor resulted in startling rises in blood glucose levels.
In order to manage this they tried using many different drugs, including the use of Metformin with very limited success. Most people had to drop out of the treatments as their glucose levels rose dangerously high. Also, for those who could stay on the treatment only got, on average a life extension of just short of one year.
His team then tried advocating a very strict ketogenic diet for a small control group and had great success for those who did stay in the diet (which was most of them). Together with the results they have on combining the ketogenic diet with a Pi3K inhibitor in rat models which, in his words, produced miraculous results they now have formal human clinical trials underway which I am confident will produce miraculous results as well.